How does chronic inflammation affect the body?

Chronic inflammation can have a significant impact on many body processes. Chronic inflammation plays a central role in some of the most challenging diseases of our time, including rheumatoid arthritis, cancer, heart disease, diabetes, asthma, and even Alzheimer’s. In fact, three out of every five people around the world die from a disease that has been linked to inflammation.

Long-term inflammation has also been shown to play a role in ageing and age related disease.

How do you know if you have chronic inflammation?

All of us will experience acute inflammation at some point in our lives either through injury, illness or both. And it’s a completely normal response the body has to repair itself. For example, if we cut our finger, the body will send inflammatory cells to the injury in order for us to heal. Similarly, if we suffer from an infection, the body will also respond in an inflammatory way. However, chronic inflammation is different to acute inflammation. Chronic inflammation is where the body continues to send inflammatory cells even when there is no outside danger.

You can diagnose chronic inflammation through a blood test that measures a protein produced by the liver, C-reactive protein (CRP), which rises in response to inflammation. A CRP level between 1 and 3 milligrams per liter of blood often signals a low, yet chronic, level of inflammation.

Common symptoms of chronic inflammation

Common symptoms of chronic inflammation include:

  • fatigue
  • body pain
  • depression or anxiety
  • gastrointestinal complications 
  • weight gain
  • weight loss
  • persistent infections


Fighting inflammation with NAD+ IV therapy

Chronic inflammation actually reduces the body’s NAD+ levels which causes more inflammation. A possible link between increased inflammation and decreased NAD+ levels is the activation of CD38. This enzyme, found in immune cells, forms cyclic adenosine diphosphate (ADP)-ribose (cADPR), ADP-ribose (ADPR), and nicotinamide (NAM). The cADPR and ADPR mediate intracellular calcium signaling, and NAM is a byproduct that enters the salvage pathway to be synthesized back into NAD+. CD38 plays a role in mitochondrial dysfunction, inflammation, immune response, metabolic disease, diet-induced obesity, cancer, oxytocin release, and social skills.

In a human cell and mouse study, researchers found that during both acute and low-grade chronic inflammation, there was an increase in CD38 activation. The researchers determined that the change in NAD+ levels were solely due to this increase in CD38. However, through NAD+ IV therapy, you can boost your NAD+ levels, short circuiting the cycle and helping to reduce inflammation.

Are you suffering from chronic inflammation?

If you’re suffering from chronic inflammation, help is available. Our NAD+ IV therapy can help fight inflammation, relieve symptoms and help you live a more happy and healthy life. Contact the clinic for more information about our revolutionary therapy.