Whether you’re gearing up to run 26.2 miles or simply supporting someone who is, marathon weekend is a celebration of dedication, discipline and pushing physical limits. But while most runners focus heavily on training plans, gear and nutrition, one often-overlooked element can have a big impact on both performance and recovery: NAD+.
This natural, powerful molecule works behind the scenes at the cellular level, fueling energy production, supporting endurance and aiding in recovery long after you’ve crossed the finish line. Here’s why NAD+ could be your not-so-secret weapon for marathon success — before, during and after race day.
What Is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme found in every cell of the body. It has many important biological roles, including energy production, repairing damaged cells, regulating inflammation and maintaining optimal mitochondrial function — all of which are critical for high physical performance.
Unfortunately, our NAD+ levels decline with age and intense physical stress, which can lead to fatigue, slower recovery and decreased cellular efficiency. That’s why topping up your NAD+ stores is especially important during periods of intense physical exertion, like marathon season.
Fuel Endurance from the Inside Out
Endurance is critical for long-distance runners, allowing them to move for longer whilst maintaining cardiovascular health. It’s all down to efficient energy production and minimising cellular fatigue, which is where NAD+ becomes essential. It can help optimise mitochondrial function, which means your cells can produce energy more effectively and sustain performance over prolonged periods of time.
With higher NAD+ availability:
- Experience improved stamina and delayed onset of fatigue.
- Muscles function more efficiently, even when under stress, helping to hit those PBs.
- Mental clarity and focus are better maintained throughout the race.
Smarter, Faster Recovery
But race day is only half the equation. What happens after the finish line is just as important.
During post-race recovery, the body works overtime to repair muscle tissue, reduce inflammation and restore energy levels. NAD+ is also integral throughout this period. By replenishing depleted NAD+ stores after the physical demands of a marathon, you’re giving your body the tools it needs to:
- Accelerate cellular repair through enhanced DNA restoration and reduced oxidative damage.
- Regulate inflammation, helping ease muscle soreness and improve mobility.
- Promote muscle regeneration by supporting protein synthesis and mitochondrial function.
Support for Every Stage of the Race
Whether you’re deep in training, approaching race day or focused on active recovery, NADclinic offers a range of NAD+ IV infusion programmes to support your goals at every step.
When delivered intravenously, NAD+ bypasses the digestive system for rapid absorption and immediate impact. From targeted pre-race formulas that optimise energy and focus, to post-race recovery infusions that help your body heal and rebuild, we have options for everyone.
Looking for something targeted to your individual needs? Our Bespoke Infusion Programme provides one-on-one expert consultation to build a personalised IV therapy plan based on your performance demands, recovery needs and overall wellness goals.
The Bottom Line
A successful run is about so much more than just crossing the finish line: it’s about how you prepare, perform and how well you recover. NAD+ supports every phase of that journey by powering your cells from within, enhancing endurance, reducing fatigue and accelerating recovery.
Whether you’re chasing a personal best or simply want to feel your strongest, NADclinic is here to help you go further. Get in touch with our friendly team today and make your next run your best one yet.
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