- Published on:Wed Jul 4
NAD+ is a critical molecule found in every cell in the body. Its primary function is to do with our metabolism and works to convert the food we eat into the energy our body’s need to function.
Our levels of NAD+ dramatically decrease as we grow older. In fact, by the time we’re 50, we have around 50% less NAD+ than we did when we were younger. By 80, NAD levels can be around just 5% of that when we were in our prime.
NAD helps manage our aging process, as well as decreasing other important aging elements including DNA damage and illness.
In fact, a study at Harvard revealed that NAD reversed the age of mice. It’s also an incredibly powerful tool in the fight against addictions – and there aren’t many addictions out there which aren’t linked to aging people both externally and internally too.
If the results of the Harvard study were to be extrapolated to a human, where the mice showed a 5% increase in lifespan following NAD+ treatment, we could on average increase our life expectancy by four years.
Here are the eight key mechanisms of NAD+ which support a reduction in the aging process:
Telomeres are stretches of DNA that cap both ends of a chromosome. These telomeres shorten over time and eventually, cell renewal stops which in turn leads to the aging or even death of the cell.
NAD+ boosts the functionality of sirtuin proteins that are directly responsible for maintaining the lengths of these critical telomeres.
DNA is highly vulnerable to damage, in-spite of its chromosomal shelter. Damage to critical DNA strands and genes not only increase the aging process but can also lead to life-shortening diseases such as cancer.
DNA can repair itself using an enzyme known as PARP-1. However, this function consumes an enormous amount of NAD+ which once depleted, significantly hinders the ability to remain NAD+ to continue repair works.
Modulation of Immune Cell Signalling
Our cells start to lose some of their focus as we age, with some becoming overactive and others more dormant. The former contributes to autoimmune diseases, whilst the latter increases risk of infection.
This cellular activity can cause a number of issues that are primarily related to mitochondrial function and energy balance – both of which depend on NAD+. Maintaining higher levels of NAD+ helps regulate immune and inflammatory pathways, including a cytokine called TNF-alpha, which is a critical cell-signaling molecule aiding longitude in proper cell function and activity.
Inducing of Energy-Intensive Enzymes
Cellular energy reduction is a universal feature of aging which we notice as decreased energy levels and higher susceptibility to illnesses and disease.
One of the causes of this energy loss is the growing inefficiency of our electron transport chains which are the main pathways by which our bodies can extract energy from food.
Studies have highlighted that restoring these electron transport chains through increased levels of NAD+ is an incredibly fast way of promoting the essential enzymes involved in energy extraction and maintaining youthful cells.
Promotion of Chromosome Stability
Chromosomes, the structures which house our DNA, can become unstable over time which can result in trigger errors in the way our genetic information and instructions are interpreted and acted upon. This process again causes the acceleration of cellular aging.
Increasing levels of NAD+ has been shown scientifically to support the crucial enzymes involved in sustaining stable chromosomal structures and their stability.
NAD+ is a Neurotransmitter
Neurotransmitters, chemicals in the brain which relay signals, regulate a number of body functions including mood, stress, and appetite. NAD+ has been shown to meet all the criteria for a neurotransmitter, including in our blood vessels and the brain itself.
In short, high levels of NAD+ nutrients has a direct correlation with sustaining the health of our brains.
Sirtuins are proteins which play a critical role in the regulation of cellular aging and DNA repair. NAD+ is required for our sirtuins to function at all and help us fight cardiovascular disease and brain function in the long-term.
Energy Production Support
As well as being a critical enzyme in the transferring of food energy into usable cellular energy, NAD+ itself has also been shown to be a form of energy currency within itself. Supporting efficient energy production and high levels of ATP both require an abundance of NAD+ within our cells, enhance energy intake from food and ensure our bodies have the high levels of energy required to both function and stave off the aging process.
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