{"id":6512,"date":"2023-12-12T12:19:05","date_gmt":"2023-12-12T10:19:05","guid":{"rendered":"https:\/\/nadclinic.com\/?page_id=6512"},"modified":"2026-05-08T15:19:42","modified_gmt":"2026-05-08T14:19:42","slug":"research-articles","status":"publish","type":"page","link":"https:\/\/nadclinic.com\/de\/research-articles\/","title":{"rendered":"Forschung & Artikel"},"content":{"rendered":"\t\t
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NAD+ Reference (increasing energy, reducing free radicals, anti-ageing)<\/strong><\/h4>\n

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Alano CC, Garnier P, Ying W, Higashi Y, Kauppinen TM, and Swanson RA. NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci 30: 2967\u20132978, 2010 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Benfeitas R, Uhlen M, Nielsen J, and Mardinoglu A. New challenges to study heterogeneity in cancer redox metabolism. Front Cell Dev Biol 5: 65, 2017 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Braidy N, Guillemin G, and Grant R. Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotox Res 13: 173\u2013184, 2008 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Braidy N, Poljak A, Grant R, Jayasena T, Mansour H, Chan-Ling T, Guillemin GJ, Smythe G, and Sachdev P. Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology 15: 177\u2013198, 2014 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Godoy JA, Rios JA, Zolezzi JM, Braidy N, and Inestrosa NC. Signalling pathway cross talk in Alzheimer's disease. Cell Commun Signal 12: 23, 2014 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Godoy JA, Zolezzi JM, Braidy N, and Inestrosa NC. Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain. Mol Neurobiol 50: 744\u2013756, 2014 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Marohnic CC, Bewley MC, and Barber MJ. Engineering and characterization of a NADPH-utilizing cytochrome b5 reductase. Biochemistry 42: 11170\u201311182, 2003 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Massudi H, Grant R, Guillemin GJ, and Braidy N. NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Rep 17: 28\u201346, 2012 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Spaans SK, Weusthuis RA, van der Oost J, and Kengen SW. NADPH-generating systems in bacteria and archaea. Front Microbiol 6: 742, 2015 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA, and Anderson CM. Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity. Glia 58: 446\u2013457, 2010 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Tao R, Kim SH, Honbo N, Karliner JS, and Alano CC. Minocycline protects cardiac myocytes against simulated ischemia-reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol 56: 659\u2013668, 2010 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Warburg O. and Christian W. Pyridine, the hydrogen transferring element of fermentation enzymes (Pyridine-nucleotide.). Biochemische Zeitschrift 287: 291\u2013328, 1936 [ Google Scholar<\/a>]<\/p>\n

Yin F, Boveris A, and Cadenas E. Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal 20: 353\u2013371, 2014 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Zeng J, Libien J, Shaik F, Wolk J, and Hernandez AI. Nucleolar PARP-1 expression is decreased in Alzheimer's disease: consequences for epigenetic regulation of rDNA and cognition. Neural Plast 2016: 8987928, 2016 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

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Clinical applications (in neurodegenerative diseases, cardiovascular risk factors, inflammatory conditions, hypoxic\/chemotoxic damages, mental health)<\/strong><\/h4>\n

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Abeti R. and Duchen MR. Activation of PARP by oxidative stress induced by beta-amyloid: implications for Alzheimer's disease. Neurochem Res 37: 2589\u20132596, 2012 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Balu M, Mazhar A, Hayakawa CK, Mittal R, Krasieva TB, Konig K, Venugopalan V, and Tromberg BJ. In vivo multiphoton NADH fluorescence reveals depth-dependent keratinocyte metabolism in human skin. Biophys J 104: 258\u2013267, 2013 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Braidy N, Grant R, Adams S, and Guillemin GJ. Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons. FEBS J 277: 368\u2013382, 2010 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Busso N, Karababa M, Nobile M, Rolaz A, Van Gool F, Galli M, Leo O, So A, and De Smedt T. Pharmacological inhibition of nicotinamide phosphoribosyltransferase\/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. PLoS One 3: e2267, 2008 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, and Auwerx J. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 15: 838\u2013847, 2012 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Diamond MP, Fletcher NM, Neubauer BR, Saed MG, H M AS, and Saed GM. Hypoxia-induced genotype switch in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase through the up-regulation of cytidine deaminase regulates postoperative adhesion development. J Minim Invasive Gynecol 22: S159, 2015 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Gensler HL. Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide. Nutr Cancer 29: 157\u2013162, 1997 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Grant RS. and Kapoor V. Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates. J Neurochem 70: 1759\u20131763, 1998 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Guyton JR. Niacin in cardiovascular prevention: mechanisms, efficacy, and safety. Curr Opin Lipidol 18: 415\u2013420, 2007 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Hershberger KA, Martin AS, and Hirschey MD. Role of NAD(+) and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol 13: 213\u2013225, 2017 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Lehmann S, Costa AC, Celardo I, Loh SH, and Martins LM. PARP mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease. Cell Death Dis 7: e2166, 2016 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Martire S, Fuso A, Mosca L, Forte E, Correani V, Fontana M, Scarpa S, Maras B, and d'Erme M. Bioenergetic impairment in animal and cellular models of Alzheimer's disease: PARP-1 inhibition rescues metabolic dysfunctions. J Alzheimers Dis 54: 307\u2013324, 2016 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Martire S, Mosca L, and d'Erme M. PARP-1 involvement in neurodegeneration: a focus on Alzheimer's and Parkinson's diseases. Mech Ageing Dev 146\u2013148: 53\u201364, 2015 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Oblong JE. The evolving role of the NAD+\/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging. DNA Repair (Amst) 23: 59\u201363, 2014 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Shetty PK, Galeffi F, and Turner DA. Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia. Neurobiol Dis 62: 469\u2013478, 2014 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Shi H, Sun N, Mayevsky A, Zhang Z, and Luo Q. Preclinical evidence of mitochondrial nicotinamide adenine dinucleotide as an effective alarm parameter under hypoxia. J Biomed Opt 19: 17005, 2014 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Soudijn W, van Wijngaarden I, and Ijzerman AP. Nicotinic acid receptor subtypes and their ligands. Med Res Rev 27: 417\u2013433, 2007 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Surjana D, Halliday GM, Martin AJ, Moloney FJ, and Damian DL. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. J Invest Dermatol 132: 1497\u20131500, 2012 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Tanno O, Ota Y, Kitamura N, Katsube T, and Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol 143: 524\u2013531, 2000 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Tong DL, Zhang DX, Xiang F, Teng M, Jiang XP, Hou JM, Zhang Q, and Huang YS. Nicotinamide pretreatment protects cardiomyocytes against hypoxia-induced cell death by improving mitochondrial stress. Pharmacology 90: 11\u201318, 2012 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Turunc Bayrakdar E, Uyanikgil Y, Kanit L, Koylu E, and Yalcin A. Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Abeta(1\u201342)-induced rat model of Alzheimer's disease. Free Radic Res 48: 146\u2013158, 2014 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Vaccari CS, Nagamia S, Thoenes M, Oguchi A, Hammoud R, and Khan BV. Efficacy of controlled-release niacin in treatment of metabolic syndrome: correlation to surrogate markers of atherosclerosis, vascular reactivity, and inflammation. J Clin Lipidol 1: 605\u2013613, 2007 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Wang H, Liang X, Luo G, Ding M, and Liang Q. Protection effect of nicotinamide on cardiomyoblast hypoxia\/re-oxygenation injury: study of cellular mitochondrial metabolism. Mol Biosyst 12: 2257\u20132264, 2016 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Wang P, Du H, Zhang RY, Guan YF, Xu TY, Xu QY, Su DF, and Miao CY. Circulating and local visfatin\/Nampt\/PBEF levels in spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. J Physiol Sci 60: 317\u2013324, 2010 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Wang P. and Miao CY. NAMPT as a therapeutic target against stroke. Trends Pharmacol Sci 36: 891\u2013905, 2015 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Wang X, Hu X, Yang Y, Takata T, and Sakurai T. Nicotinamide mononucleotide protects against beta-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res 1643: 1\u20139, 2016 [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n

Wei CC, Kong YY, Li GQ, Guan YF, Wang P, and Miao CY. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2\/HO-1 signaling pathway. Sci Rep 7: 717, 2017 [ PMC free article<\/a>] [ PubMed<\/a>] [ Google Scholar<\/a>]<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

KNOWLEDGEBASE Research & Publications Research & Articles NAD+ Reference (increasing energy, reducing free radicals, anti-ageing)   Alano CC, Garnier P, Ying W, Higashi Y, Kauppinen TM, and Swanson RA. NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci 30: 2967\u20132978, 2010 [ PMC free article] [ PubMed] [ Google Scholar] Benfeitas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6512","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/pages\/6512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/comments?post=6512"}],"version-history":[{"count":6,"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/pages\/6512\/revisions"}],"predecessor-version":[{"id":13379,"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/pages\/6512\/revisions\/13379"}],"wp:attachment":[{"href":"https:\/\/nadclinic.com\/de\/wp-json\/wp\/v2\/media?parent=6512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}